Role of Smoking in Thrombus Formation Smoking significantly increases the risk of thrombus (blood clot) formation through various mechanisms, primarily by affecting platelet activity, coagulation factors, and endothelial function. Smoking acutely enhances platelet aggregation and thrombus formation, especially in individuals with existing cardiovascular conditions. It also alters coagulation factors, promoting a prothrombotic state and impairing fibrinolysis. | Dr. Najeeb