Prolonged Effects of Anger-Related Cortisol Elevation If anger becomes chronic or frequent, sustained high cortisol levels can have negative effects, including: Impaired Cognition: Prolonged cortisol exposure can affect memory and decision-making. Weakened Immune System: Chronic cortisol elevation can suppress immunity, making the body more prone to illness. Increased Risk of Health Issues: Conditions such as high blood pressure, heart disease, and anxiety can arise from long-term cortisol dysre