Leukocyte extravasation - Wikipedia
Experiments have found that a force-dependent decrease in off-rates dictated flow-enhanced rolling of L-selectin–bearing microspheres or neutrophils on PSGL-1. [5] Catch bonds enable increasing force to convert short bond lifetimes into long bond lifetimes, which decrease rolling velocities and increase the regularity of rolling steps as ...
Neutrophil transendothelial migration: updates and new …
May 16, 2019 · The neutrophil recruitment cascade to inflamed tissues involves elements of neutrophil rolling, firm adhesion, and crawling onto the EC surface before extravasating by breaching the EC barrier.
Neutrophil transendothelial migration: updates and new
May 16, 2019 · Neutrophils represent the first line of cellular defense against invading microorganism by rapidly moving across the blood-endothelial cell (EC) barrier and exerting effector cell functions. The neutrophil recruitment cascade to inflamed tissues involves elements of neutrophil rolling, firm adhesion …
Neutrophil recruitment and function in health and inflammation
Feb 25, 2013 · Rolling neutrophils have to overcome a high shear stress of blood and a tensile stretch originating from rolling. They restrain those forces by using adhesive bonds that form at the front and...
The Neutrophil’s Role During Health and Disease
Feb 13, 2019 · Neutrophils rolling along endothelium have to overcome the blood shear stress as well as the original tensile stretch from rolling. These forces are restrained through the use of adhesive bonds that form at the front of the rolling cell and break at the rear.
Rolling neutrophils form tethers and slings under physiologic ...
Dec 28, 2017 · Human and mouse neutrophils are known to form tethers when rolling on selectins in vitro. Tethers are ∼0.2 μm thin, ∼5–10 μm‐long structures behind rolling cells that can swing around to form slings that serve as self‐adhesive substrates.
Neutrophils: Molecules, Functions and Pathophysiological Aspects …
May 1, 2000 · The rolling step is mediated by neutrophil L-selectin and by E- and P-selectins newly expressed on inflamed endothelial cells.
‘Slings’ enable neutrophil rolling at high shear | Nature
Jul 1, 2012 · In this study, Klaus Ley and colleagues describe novel structures called 'slings' (an analogy to the ancient weapon) that provide a 'carpet' of adhesive substrate in front of rolling...
Selectin-Mediated Signaling—Shedding Light on the Regulation of ...
Selectin-dependent integrin activation during neutrophil capturing and rolling mediates the activation of LFA-1, necessary for neutrophil slow rolling and subsequent recruitment. Key molecules involved in different recruitment steps are indicated below.
Leukocyte–Endothelial Cell Adhesion - Inflammation and the ...
Selectins are lectin-like adhesion glycoproteins that mediate leukocyte rolling, which serves to sufficiently reduce the velocity of leukocyte movement along endothelial cell to allow for firm adhesion. P-selectin can be expressed by both EC and platelets, while E-selectin is only expressed by EC.