Mar 1, 2024 · Excedrin is used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, or nasal congestion. Excedrin may also be used for purposes not listed in this medication guide. Warnings. Do not give Excedrin to a child or teenager with a fever, flu symptoms, or chicken pox.