Scientists at St. Jude Children's Research Hospital have reconciled two closely related but contentious mechanisms underlying ...

1. The Biological Role of TNF-α “If the immune system is a fire brigade, TNF-α is the chief who sounds the alarm,” explains Dr. Anil Mukherjee, a molecular biologist at Johns Hopkins.

The structure of 166416 gene chains of various dimensions consisting of polylocus combinations of 12 polymorphic positions which forming cytokine gene network which associated with the development of ...

Highlights 1. Emodin exhibits excellent anti RA activity. 2. Emodin can effectively target and inhibit the activity of TNF-α. 3. By binding directly to TNF-α and stabilizing its asymmetric trimeric ...

Ricky Hollywood recaps the exhilarating matchup against the Buffalo Bills on Sunday and gives this week's coin toss. NFL Network's Colleen Wolfe joins the show to talk about the impressive win, look ...

As the first crystal structure of this type, the researchers say it will also be useful as a model for other targets in the genome, besides the insulin gene, which form this shape of DNA.

Tuberculosis in otherwise healthy adults with inherited TNF deficiency. Nature, 2024; DOI: 10.1038/s41586-024-07866-3 ...

In these two patients, the TNF gene failed to function, preventing the respiratory burst from occurring, and thus the creation of ROS molecules. As a result, the patients' alveolar macrophages ...

Without TNF, a key part of the defense against it is defunct. The findings may lead to a radical reassessment of TNF’s role in immune function—and new treatment possibilities.

A goal of gene therapies in the future will be targeting and correcting this mutation, Aydin says. "In science, we call this the bottom-up approach," he says.

Article citations More>> Wu, H. and Hymowitz, S.G. (2009) Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface. 2nd Edition, Handbag Cell Signal, 265-275. has been cited by the ...

Meitheal bets there is still life in TNF inhibitors, paying Xentria $45M for lung disease therapy By Nick Paul Taylor Jun 27, 2023 6:00am Meitheal Pharmaceuticals lung disease Anti-TNF biotech deals ...