Showcasing her meaningful work at the San Jose Family Shelter and adoration for her father, join us as we celebrate 49ers superfan Sofia Villalpando, the 2024 49ers Fan of the Year, presented by ...

The NFL and USAA, an official NFL Salute to Service partner, announced San Francisco 49ers tight end George Kittle alongside Minnesota Vikings running back Aaron Jones and Los Angeles Chargers ...

GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury.

GLENDALE -- San Francisco 49ers TE George Kittle will play in Week 18's regular season finale against the Arizona Cardinals. Kittle was questionable with hamstring/ankle injuries entering this week.

James Conner will not play in the Arizona Cardinals’ season finale against the San Francisco 49ers. He was placed on injured reserve earlier this week, ending his season. Several other Cardinals ...

San Francisco 49ers Head Coach Kyle Shanahan announced the team would start Joshua Dobbs in their season finale at home against the Arizona Cardinals, Dobbs’ former team. Dobbs takes the reigns ...

One year after coming three points short of a championship in Super Bowl LVIII, the San Francisco 49ers aren't returning to the playoffs and will own a losing record. But change will not be coming ...

Tensions were high in the first quarter of a Monday night game between the Detroit Lions and the San Francisco 49ers. The Lions were looking for one more win to build momentum ahead of an NFC ...

Jared Goff threw three touchdown passes as the Detroit Lions overpowered the San Francisco 49ers 40-34 in a high-scoring thriller on Monday Night Football. After the 49ers impressed in the first ...

The 49ers host the Lions in a Week 17 Monday Night Football game. San Francisco is out of playoff contention, while Detroit seeks the top seed. The Lions miss star running back David Montgomery ...

This week's Monday Night Football game between the Detroit Lions and the San Francisco 49ers won't have playoff implications for either team, whose post-season fates have already been determined.