Find more information on the Altmetric Attention Score and how the score is calculated. Definitive prion disease diagnosis is currently limited to postmortem assay for the presence of the ...

Upon intracerebral injection into susceptible species, prions are capable of inducing a progressive, invariably lethal disease of the central nervous system. However, in bovine spongiform ...

Figure 1: FACS analysis of spleen cells from BM-grafted uninfected mice, stained with PrP-specific antibody (open histograms) or unstained (shaded histograms). Figure 2: Confocal analysis of ...

Head lice are insect parasites that live on the human scalp to reproduce and feed on its blood. While not dangerous, an infestation can cause severe itchiness and irritation, leading to secondary ...

Nature is full of wonders, and nowhere is this more evident than in the animal kingdom’s unique methods of reproduction. From the depths of the ocean to the tropical forests, animals have evolved ...

Patient Preparation PRNP Testing will not be performed in patients under 18 years of age. Specimen Type Peripheral Whole Blood. Preferred Container Ethylenediaminetetraacetic acid (EDTA). Specimen ...

A paper published in PLoS Biology in June 2020 by Dr Emmanuel Asante and other scientists at the Institute showed the first ever genetically modified mouse model which can directly mimic aspects of an ...

This looks at the causative agent of such disease – prions. In particular, misfolded tau proteins are the hallmark of Alzheimer’s disease and frontotemporal dementia Prions are a type of ...

Prions are of major interest in biology. Not only are they infectious agents capable of entering and colonising a host and evading its defences while being composed essentially of a single polypeptide ...

Thus, the term ‘gestateling’ should be adopted to refer to this new product of human reproduction: a developing human being gestating ex utero. While this paper does not attempt to solve all the ...

Prion-like proteins can propagate across species, potentially contributing to disease. Here the gut microbiome was analyzed to predict and define a set of exogenous prion-like sequences. Their ...

unibo.it Objective To compare the diagnostic accuracy and the prognostic value of blood and cerebrospinal fluid (CSF) tests across prion disease subtypes. Methods We used a single-molecule immunoassay ...