Here, we constructed a functionalized bone substitute by combining application of the demineralized bone matrix (DBM) and collagen-binding stromal-cell-derived factor-1α (CBD-SDF-1α). DBM was a ...

Skeletal remodeling is mediated by the integrated and tightly coupled actions of mechano-sensing osteocytes, bone-resorbing osteoclasts and bone-forming osteoblasts (Figure 1).

Metabolic bone disease (MBD), as one of the most severe metabolic disorders ... employed magnetic bead-based weak cation exchange chromatography combined with matrix-assisted laser ...

Osseointegration is the scientific term for bone ingrowth into a metal implant. An artificial implant is permanently, surgically anchored and integrated into bone, which then grows into the implant.

The STXM analysis revealed that the matrix of SM2-5 contains C-rich grains, possibly organic nanoglobules. A single carbonate grain was also detected. The C-XANES spectrum of the matrix is similar to ...

The increased amounts of normal collagen fibers deposited by these cells might well have provided a matrix for the deposition of mineral, resulting in stronger bone that persisted longer than most ...

Our results represent the first in vivo research on ND (or NDPC) as nanofillers in a polymer matrix for bone tissue engineering. The high mechanical properties, good in vitro and in vivo ...

In AS and OPLL, fibroblasts respond to inflammatory signals and mechanical stress, contributing to pathological bone formation through extracellular matrix remodeling and osteogenic gene expression.