A mineralocorticoid receptor antagonist that blocks excess aldosterone and reduces fluid volumes, spironolactone is the ...

Advances in heart failure treatment have reduced hospitalizations by up to 30% and extended lives by years. Learn about ...

We wanted to see if the new nonsteroidal mineralocorticoid receptor antagonist finerenone had similar effects across the cardio-kidney-metabolic spectrum.” Pabon and colleagues found that ...

such as mineralocorticoid receptor antagonists, have limitations -- among them, compensatory increases in serum aldosterone levels, off-target effects, and concerns about acceptability to patients.

High blood pressure frequently occurs in people with diabetes. Learn about the relationship, risks, and treatments for ...

The effect of lorundrostat on renal function ... potentially overcoming limitations of mineralocorticoid receptor antagonists such as compensatory aldosterone elevation and poor tolerability.

The effects of lorundrostat administration over ... lorundrostat and alternative antihypertensive medications, including mineralocorticoid receptor antagonists. In this trial, aldosterone synthase ...

AR = Androgen receptor; ER = Estrogen receptor; GR = Glucocorticoid receptor; MR = Mineralocorticoid receptor ... a primary prediction of the potential effects of a compound.

The oral, non-steroidal mineralocorticoid receptor (MR ... but has been affected by side effect concerns which – while resolved – have sent its sales into reverse gear. Bayer has emphasises ...

It's not clear how GLP-1 drugs exert their beneficial effects in cardiovascular diseases ... Bayer has filed its mineralocorticoid receptor antagonist finerenone as a treatment heart failure ...