Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited tumor-infiltrating lymphocytes (TILs) may be ...

Dr. Hyung L. Kim discusses how the addition of cytoreductive nephrectomy to ICI therapy may affect survival and quality of ...

Purpose: The role of sunitinib and sorafenib in the treatment of metastatic renal cell carcinoma (mRCC) is reviewed. Conclusion: The tyrosine kinase inhibitors sorafenib and sunitinib offer ...

April 16, 2025 A Nationwide Real-world Evaluation of Upfront Cytoreductive Nephrectomy in Patients with Synchronous Metastatic Renal Cell Carcinoma in the Immunotherapy Era. April 15, 2025 ...

BRAF belongs to the RAF kinase family and is involved in the Ras/Raf/MEK/ERK signaling pathway, which is associated with cell proliferation and growth (42). Thyroid cancer frequently has BRAF ...

1Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, California.

Patients were stratified by International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk groups: favorable vs intermediate vs poor. The trial was designed to reach 80% power with 385 ...

Results of a meta-analysis suggest that enfortumab vedotin plus pembrolizumab is more effective than chemotherapy as first-line treatment for patients with metastatic urothelial cancer ...

Researchers at Dana-Farber found that in clear cell renal cell carcinoma, a common form of kidney cancer, dormant viral genes embedded in human DNA can be reactivated due to mutations, triggering an ...

The detection of metastases in Merkel cell carcinoma (MCC) requires additional testing, such as pancytokeratin (panCK) or CK20, with no guarantee of success. Recent findings have identified ...