The San Francisco 49ers have had terrible injury luck this season, which ultimately led to the end of their playoff hopes. Just a few months ago, they were in the overtime of a Super Bowl, but life ...

The San Francisco 49ers list of players on injured lists ballooned to 16 ... wide receiver Brandon Aiyuk and running back ...

The 49ers are in a good spot to land pass rush help … or Ashton Jeanty … in the 1st round of this year’s draft.

Rookie running back Isaac Guerendo was carted off the field less than two minutes into the first quarter during the 49ers’ ...

"After losing RBs Christian McCaffrey, Jordan Mason, and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday's game vs. Miami.

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

Being prepared for what life throws at him is a specialty for 49ers running back Patrick ... Not only have the Niners lost Christian McCaffrey and Jordan Mason to IR, backup Isaac Guerendo ...

The other running backs on the 49ers' 53-man roster are Patrick Taylor Jr. and Israel Abanikanda. Taylor is expected to get the first shot to replace Guerendo. The 49ers also have running back ...

The running back room has been hit especially hard, headlined by injuries to Christian McCaffrey, Jordan Mason and Elijah Mitchell. Putting the "next man up mentality" to the test, the 49ers are a ...

On Sunday, the San Francisco 49ers traveled to State Farm Stadium to take on the Arizona Cardinals, looking for only their seventh win of the season.

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The ...