Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian ...

Getting hurt the Sunday before a Thursday night game gave San Francisco 49ers fans plenty of reason to be skeptical about ...

The San Francisco 49ers running back is questionable with a sprained foot, but per ESPN’s Adam Schefter: he “plans to play” ...

The 49ers host the Rams on Thursday Night Football. They’ve been losing running backs left and right, and now we’re awaiting ...

The 49ers won’t be down to their 4th-string running back tonight against the Rams as Isaac Guerendo is expected to play ...

The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

San Francisco 49ers running back Isaac Guerendo has a foot sprain, per head coach Kyle Shanahan. 49ers HC Kyle Shanahan said ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

According to ESPN's Adam Schefter, San Francisco 49ers rookie running back Isaac Guerendo is expected to suit up for Thursday ...

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being ...