Guerendo was the 49ers' fourth-round pick in the 2024 NFL draft. He's also played in all 11 games for the Niners, but hasn't started any of them. Veteran Elijah Mitchell has been on season-ending ...

Isaac Guerendo rushed for a touchdown for San Francisco, which lost its third straight game. The 49ers lost star running back Christian McCaffrey in the second quarter due to a knee injury.

Turnovers defined the day for the 49ers, as they committed three in total, struggling to gain any momentum despite a touchdown from running back Isaac Guerendo. Meanwhile, Josh Allen and Amari ...

Mason finished with 13 carries for 78 yards, and rookie backup Isaac Guerendo scored the Niners' lone touchdown of the night, bursting off the left side from 15 yards out. The result is a 5-7 team ...

With Christian McCaffrey ruled out for the remainder of the game with a knee injury, the San Francisco 49ers run game went through Jordan Mason and rookie Isaac Guerendo on Sunday Night Football ...

ORCHARD PARK, N.Y. — These are the cold, hard facts. The 49ers received another snowball upside their heads — figuratively and, perhaps, literally — when the Buffalo Bills hit them with a 35 ...

Moody opened the scoring with a 33-yard field goal and Isaac Guerendo scored on a 15-yard run. Brock Purdy, coming back after missing one game with a sore throwing shoulder, finished 11 of 18 for ...

With Christian McCaffrey unavailable because of leg injuries and Isaac Guerendo needing time to adjust to the pros, Mason broke out, having a few 100-yard games and being a decent rushing presence ...

Watch San Francisco 49ers tight end George Kittle's Week 14 highlights as he caught six passes for 151 yards against the Chicago Bears. Watch San Francisco 49ers quarterback Brock Purdy's best ...

Garner thanked Birdie "for being the world’s best dog" Jennifer Garner/instagram Jennifer Garner is saying goodbye to her dog Birdie. On Wednesday, Nov. 27, the Deadpool & Wolverine actress ...