Watch San Francisco 49ers tight end George Kittle's Week 14 highlights as he caught six passes for 151 yards against the Chicago Bears. Watch San Francisco 49ers quarterback Brock Purdy's best ...

With Christian McCaffrey ruled out for the remainder of the game with a knee injury, the San Francisco 49ers run game went through Jordan Mason and rookie Isaac Guerendo on Sunday Night Football ...

And the running game was good. Jordan Mason and Isaac Guerendo had emerged as an elite running-back tandem. Mason is one of the hardest runners in the NFL and Guerendo is one of the fastest.

San Francisco 49ers rookie RB Isaac Guerendo punched in a touchdown in the team's Week 14 matchup against the Chicago Bears. San Francisco 49ers QB Brock Purdy connected a 16-yard touchdown pass ...

Rams, but bad news elsewhere San Francisco 49ers | Why 49ers need Isaac Guerendo against the Rams The Seattle Seahawks defeated the San Francisco 49ers 20-17 with a 13-yard rush into the end zone ...

With Christian McCaffrey unavailable because of leg injuries and Isaac Guerendo needing time to adjust to the pros, Mason broke out, having a few 100-yard games and being a decent rushing presence ...

But to get McCaffrey on the field, the 49ers have buried running backs Jordan Mason and Isaac Guerendo who were playing extremely well. So suddenly, the 49ers running game has become a big weakness.

Isaac Guerendo injury update: 49ers RB goes to locker room in fourth quarter vs. Bears The 49ers backfield is further and further depleted. Running back Isaac Guerendo is the latest to suffer an ...

In Seattle, the 49ers rushed for 233 yards. And that's because Jordan Mason and Isaac Guerendo were outstanding. Mason averaged 8.1 yards per carry and Guerendo averaged 9.9. And combined ...