Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

ESPN’s Adam Schefter reported that San Francisco 49ers running back Isaac Guerendo will try to play tonight against the Los ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

Isaac Guerendo is expected to step in as the San Francisco 49ers' starting running back after injuries to Christian McCaffrey ...

Guerendo has steadily improved this season and will step up in Christian McCaffrey and Jordan Mason's absence.

The San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by a former Offensive Player of ...

DE Nick Bosa (hip, oblique), RB Isaac Guerendo (foot) and LB Dre Greenlaw (Achilles ... Unsurprisingly, a running back with size (6-0, 221 pounds) and speed (4.33 40-yard dash) performed well in Kyle ...

There's even a chance Guerendo, who pulled his hamstring on the first day of training camp and missed the first two preseason ...

A situation developed just before the Fantasy playoffs that delivered us a potential league-winning running back. Christian ...