Among them is gemcitabine, a pyrimidine antimetabolite. 13–17 Gemcitabine is well tolerated and can be safely used in patients with impaired renal function (GFR ≥ 30 mL/min). 18 Trial history and ...

Gemcitabine, a drug with established efficacy against a number of solid tumors, has therapeutic limitations due to its rapid metabolic inactivation. The aim of this study was the development of an ...

Nintedanib (BIBF1120) is a potent, oral, small-molecule tyrosine kinase inhibitor, also known as a triple angiokinase inhibitor, inhibiting three major signaling pathways involved in angiogenesis.

Doctors often use chemotherapy to treat pancreatic cancer that has spread. One of the drugs used is gemcitabine. Acelarin is a type of chemotherapy.It is a similar drug to gemcitabine, but scientists ...

Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease and cytotoxic chemotherapy is the standard of care treatment for patients with advanced disease. Here, we investigate ...

Figure 1 Inhibition of AsPC-1 cell growth by OxA and/or gemcitabine.(A) Inhibition of AsPC-1 cell viability induced by 0.01 µM gemcitabine (gem), 0.1 µM OxA (OxA), or 0.01 µM gemcitabine plus 0.1 µM ...

A phase 2 trial in PAC demonstrated the safety and preliminary efficacy of TTFields therapy with gemcitabine with or without nab-paclitaxel. We report final data from PANOVA-3 (NCT03377491), the ...

Section 1 Class B boys lacrosse at Yorktown: Horace Greeley 17, Yorktown 15 Section 1 Class C boys lacrosse at Yorktown: Somers 12, Rye 7 YORKTOWN HEIGHTS – Mamaroneck wants more. The Tigers ...