Figure 1: Generation of mice deficient for Gr in the nervous system. Figure 2: Mice lacking Gr in the nervous system display symptoms characteristic of Cushing syndrome including reduced size ...

1 Lorundrostat is a highly selective aldosterone synthase inhibitor that investigators hypothesize may be effective in lowering blood pressure by directly targeting aldosterone biosynthesis with fewer ...

"Current therapeutic approaches targeting aldosterone, such as mineralocorticoid receptor antagonists, have limitations -- among them, compensatory increases in serum aldosterone levels ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Primary cilia are cell signalling and ...

2 Non-Profit Research Association Alliance for the Promotion of Preventive Medicine (APPREMED), Mechelen, Belgium Objective Heart failure (HF) is characterised by collagen deposition. Urinary ...

2 University College London Hospitals NHS Foundation Trust, London, UK Background and aims Mineralocorticoid receptor antagonists (MRAs) reduce mortality and hospitalisation in heart failure with ...

Hubei Key Laboratory of Purification and Application of Plant Anti-Cancer Active Ingredients, Department of Chemistry and Life Science, Hubei University of Education, Wuhan, 430205, China ...

School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, ...

In clinical trials, Trulicity and Victoza have also shown protective benefits for the kidneys. 8. Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone (Kerendia) is currently the only ...

This study explored how specific early attention mechanisms-namely, exogenous attention allocation and joint attention initiation-during mother-infant interactions at 12 months may influence language ...