The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...

The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have started ...

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The ...

The 49ers injury woes continue at running back after Isaac Guerendo was carted off the field in the 1st quarter.

The last-place 49ers (6-11) lost seven of their final eight and did so with a generous defense that failed to produce a ...

Kyle Juszczyk addresses potentially leaving the team in free agency after the team's final game of the 2024 season ...

Among those listed as “out” Friday by 49ers coach Kyle Shanahan were wide receiver Deebo Samuel (rib/wrist), cornerback ...

Cardinals cornerback Max Melton exited Sunday's season finale against the 49ers with a wrist injury, and the club announced ...

The San Francisco 49ers ended a disastrous 2024 NFL season on Sunday with plenty more things going horribly wrong against the Arizona Cardinals.

The 49ers have signed two other veteran wideouts ... The others are Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring). Guerendo, a 2024 fourth-round pick, proved ...

The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have started ...

Rookie Isaac Guerendo battled injuries himself after taking the lead role in the backfield, and was carted off during the ...