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In a groundbreaking study published in Nature Chemistry, researchers have unveiled an unprecedented, comprehensive profiling of electrophile interactions across the proteome, revealing insights that ...

Cross-electrophile coupling (XEC) is a powerful strategy for forming C–C bonds in synthetic organic chemistry. While XEC reactions between two electrophiles are well established, those involving three ...

Students need to have a fluency across a range of concepts and skills to gain a secure grasp of organic chemistry. In terms of reaction mechanisms, research has shown that learners frequently have ...

Misbehaving proteins are behind many diseases. One way drugmakers incapacitate these bad actors is to deploy molecules that bind to them. But finding solid footholds on the proteins to block their ...

Chemists are amped up about two new reactions that use electricity to form different types of carbon-carbon bonds. One transformation builds sp 3-sp 3 C–C bonds and the other creates sp 2-sp 3 C–C ...

In general, an electrophile is a highly reactive compound that "seeks" to bond with atoms or other molecules that have an available electron pair. In the buzzing hive of activity that is the cell, ...

Although alcohols are one of the largest pools of alkyl substrates, approaches to utilize them in cross-coupling and cross-electrophile coupling are limited. We report the use of 1° and 2° alcohols in ...