"Centrosome amplification is found in human tumors but not in normal cells, so it is an appealing feature to explore for diagnosis, prognosis, and therapy," explains Carla Lopes, ...

“Centrosome amplification is found in human tumors but not in normal cells, so it is an appealing feature to explore for diagnosis, prognosis, and therapy,” explains Carla Lopes, ...

The antineoplastic drug hydroxyurea (HU), when used at subtoxic doses, induces prolonged replication stress and centrosome amplification. This causes genomic instability and increases the ...

Centrosome amplification is a frequent phenomenon in malignancies and may facilitate tumorigenesis by promoting chromosomal instability. On the other hand, a centrosome inactivation checkpoint ...

Cells begin to accumulate centrosomes—organelles that play a vital role during cell division—before they transform into cancer cells, according to a new study of patients with Barrett's ...

Amplification of key cellular organizer may initiate cancer Date: May 8, 2018 Source: Rockefeller University Press Summary: Cells begin to accumulate centrosomes -- organelles that play a vital ...

By Bob Grant Hold the centrosomes Dr Geoffrey A. Charters / Auckland Cancer Society Research Centre The paper: R. Basto et al., “Centrosome amplification can initiate tumorigenesis in flies,” Cell, ...

OVERCROWDED: A cell with too many centrosomes (each with two centrioles; green), extra mitotic spindles (red), and abnormally segregated DNA (blue) BRAMWELL LAMBRUS, HOLLAND LAB The paper M.S. Levine ...

The cover for issue 26 of Oncotarget features Figure 6, 'Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells,' by Osman, et al. and reported ...

Background: Centrosome amplification (CA) has been reported in all human cancers and is thought to result in aneuploidy and chromosomal instability (CIN). CA is associated with deleterious clinical ...

Background: Centrosome amplification (CA) which refers to presence of supernumerary or abnormally large centrosomes is believed to drive tumor progression by promoting chromosomal instability and the ...

This is known as centrosome amplification. Prof. Royle explained the recent study, saying: “The authors found that cells with too many centrosomes […] secrete tiny packets called small ...