The classic view of the cell cycle was established by pioneering experiments in yeast and sea urchins by Hartwell, Nurse, Hunt, and others. 3 In principle, the cell cycle represents the molecular ...

Recent work revealed new insights into the temporal regulation of G1–S cell cycle transcription, during proliferation and in response to activation of the DNA replication checkpoint. This has ...

The cell cycle also serves to protect the cell from DNA damage. Thus, cell cycle arrest, in fact, represents a survival mechanism that provides the tumor cell the opportunity to repair its own damaged ...

For example, upon leucine withdrawal, MCF10A cells complete two cell cycles and then enter a CDK2-low quiescence, whereas lysine withdrawal causes immediate cell-cycle stalling. Methionine withdrawal ...

Discovery within human cell cycle process to bring new understanding of cellular diseases Date: July 27, 2021 Source: University of Kent Summary: New research has uncovered an essential mechanism ...