The classic view of the cell cycle was established by pioneering experiments in yeast and sea urchins by Hartwell, Nurse, Hunt, and others. 3 In principle, the cell cycle represents the molecular ...

Table 2 Cell cycle classification results from the imaging framework for the Fucci2-positive cells analyzed. Full size table. Table 3 Imaging framework classification characteristics, ...

Recent work revealed new insights into the temporal regulation of G1–S cell cycle transcription, during proliferation and in response to activation of the DNA replication checkpoint. This has ...

Cell cycle speed is key to making aging cells young again Date: January 30, 2014 Source: Yale University Summary: Researchers identified a major obstacle to converting cells back to their youthful ...

For example, upon leucine withdrawal, MCF10A cells complete two cell cycles and then enter a CDK2-low quiescence, whereas lysine withdrawal causes immediate cell-cycle stalling. Methionine withdrawal ...

The cell cycle also serves to protect the cell from DNA damage. Thus, cell cycle arrest, in fact, represents a survival mechanism that provides the tumor cell the opportunity to repair its own damaged ...

Discovery within human cell cycle process to bring new understanding of cellular diseases Date: July 27, 2021 Source: University of Kent Summary: New research has uncovered an essential mechanism ...