Here, we constructed a functionalized bone substitute by combining application of the demineralized bone matrix (DBM) and collagen-binding stromal-cell-derived factor-1α (CBD-SDF-1α). DBM was a ...

Although in vitro results suggest collagenase activity for membrane-bound matrix metalloproteinase type 1 (MMP-14), in vivo evidence for such a function in atherosclerosis remains scant. Conclusion— ...

Overall, these results demonstrate the multiple functions of nanosilicates conducive to the regeneration of bone in nonunion defects, including increased network stiffness and porosity, injectability, ...

This content was created by our physicians and experts. By Alana C. Serota, MD, CCFP, CCD Osteoporosis has been called a "silent" disease because the loss of bone progresses gradually without pain or ...

A high level of OPN suppresses the secretion of proinflammation cytokines and matrix-degrading enzymes, alleviates bone mass reduction, and promotes bone formation as well as matrix calcification in ...

In AS and OPLL, fibroblasts respond to inflammatory signals and mechanical stress, contributing to pathological bone formation through extracellular matrix remodeling and osteogenic gene expression.

Your bone marrow is supposed to be your body’s reliable blood cell factory, churning out healthy red cells, white cells, and platelets like clockwork. But sometimes this vital production system ...

Subchondral sclerosis is the hardening of the bone just below the cartilage surface. It shows up in the later stages of osteoarthritis. Subchondral sclerosis is common in the bones found at the ...

Dubbed the “bone collector,” this caterpillar species scrounges the cadavers — and sometimes the live bodies — of insects from spider webs, carefully rotating them in an almost curated manner in order ...