With running backs Christian McCaffrey and Jordan Mason on IR, the 49ers turned to rookie RB Isaac Guerendo to start their ...

The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

Isaac Guerendo was elevated from third-string running back to the 49ers starter in Week 14, filling in for Christian ...

Stafford is arguably the best quarterback in the NFL when he can operate from a clean pocket — he has thrown for 2,656 yards ...

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...

Being prepared for what life throws at him is a specialty for 49ers running back Patrick Taylor Jr., whether it’s the ...

The San Francisco 49ers are moving forward without star running back Christian McCaffrey or backup Jordan Mason for the ...

Here's everything you need to know about the 49ers current RB depth chart following injuries to Christian McCaffrey and ...

The San Francisco 49ers’ exceedingly deep backfield thinned out rapidly when running backs Christian McCaffrey and Jordan ...

The 49ers lost running back Christian McCaffrey for the season with a knee injury. His backup, Jordan Mason, will also be ...