Things seemed to be turning around for the 49ers after a 38-13 win over the Chicago Bears on Sunday until their Thursday ...

For months, it has hung over the 49ers. Call it a hangover, a letdown, or karmic retribution, but 12 weeks into the season, they haven’t been able to shake it. In fact, it just keeps getting worse.

For Week 12, there’s an epic matchup between two NFC rivals with the San Francisco 49ers (5-5) taking on the Green Bay Packers (7-3). Both teams are fighting to win this season, but the Packers ...

The San Francisco 49ers could be nearing the end of a long run as title contenders. Not only are the 49ers now in last place in the NFC West, thanks to their blowout loss in Green Bay on Sunday ...

The San Francisco 49ers and coach Kyle Shanahan are undefeated against the Green Bay Packers and Matt LaFleur when it matters most — in the playoffs. But Sunday is not a playoff game.

The 49ers added another name to their long list of players out for Sunday's game against the Green Bay Packers. Offensive lineman Jon Feliciano, who was listed as questionable with a knee injury ...

On Thursday, San Francisco 49ers head coach Kyle Shanahan was hopeful Brock Purdy would play against the Green Bay Packers in Week 12. On Friday, the 49ers ruled the third-year quarterback out for ...

The San Francisco 49ers, 5-5 and in last place in the NFC West, desperately need a win if they want to keep their playoff hopes alive. Now, they have an even steeper uphill climb after it was ...

The San Francisco 49ers have battled injuries to some of their best weapons this season, and that trend continued this week, with quarterback Brock Purdy nursing a shoulder issue ahead of Week 12.

The Packers take on the San Francisco 49ers at 3:25 p.m. Sunday at Lambeau Field. This will be the second late afternoon start time at home for Green Bay this season. What's the weather forecast ...