Drug reaction with eosinophilia and systemic symptoms (DRESS) is a T-cell–mediated severe cutaneous adverse reaction characterized by rash, fever, internal organ involvement, and systemic ...

Standard treatment for multibacillary leprosy is multidrug therapy consisting of dapsone, rifampicin, and clofazimine, with a recommended treatment duration of 12 months. 4 Challenges include ...

Overall, 874 patients underwent randomization, with 331 assigned to imlunestrant, 330 to standard therapy, and 213 to imlunestrant–abemaciclib. Among 256 patients with ESR1 mutations, the median ...

The Sepsis-1, Sepsis-2, and Sepsis-3 definitions are for adult sepsis. The IPCC (International Pediatric Sepsis Consensus Conference) and Phoenix definitions are for pediatric sepsis. ARDS denotes ...

Participants received CD68-ET3-LV–transduced autologous CD34+ HSCs at doses of 5.0×10 6 to 6.1×10 6 per kilogram of body weight. The vector copy numbers in the final drug product were 1.0 and ...

Xalnesiran, a small interfering RNA molecule that targets a conserved region of the hepatitis B virus (HBV) genome and silences multiple HBV transcripts, may have efficacy, with or without an ...

The effect of a liberal red-cell transfusion strategy as compared with a restrictive strategy in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear.

Dr. Kathleen M. McFadden (Medicine): A 22-year-old woman was transferred to this hospital in the summer before the coronavirus disease 2019 pandemic because of headache, fever, and respiratory ...

Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma ...

Dr. Vandana L. Madhavan: A 30-month-old boy was admitted to this hospital for the third time in 4 weeks because of recurrent fever. The patient had been well until 4 weeks before the current ...

Cell-free DNA (cfDNA) sequence analysis to screen for fetal aneuploidy can incidentally detect maternal cancer. Additional data are needed to identify DNA-sequencing patterns and other biomarkers ...

B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common childhood cancer. Despite a high overall cure rate, relapsed B-cell ALL remains a leading cause of cancer-related death among ...