Such findings were generally ignored because multiple epidemiological studies have demonstrated reduced cardiovascular disease (CVD) events with increasing levels of physical activity (PA). Randomized ...

In the recent article, “Antisense Oligonucleotide Therapy for Calmodulinopathy,” we provided the first proof-of-concept in ...

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The recent study by Bortolin et al, 1 “Antisense Oligonucleotide Therapy for Calmodulinopathy,” presents an innovative therapeutic strategy for rare inherited arrhythmia syndromes. By leveraging ...

Elevated plasma levels of Lp(a) [lipoprotein(a)] are a causal risk factor for coronary heart disease and stroke in European individuals, but the causal relevance of Lp(a) for different stroke types ...

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The adult vascular system is a developmental mosaic. This is particularly true for vascular SMCs that comprise the medial layer of blood vessels throughout the body. 1 SMCs are specialized ...

Cardiac channelopathies, also known as primary electrical heart diseases, are inherited genetic abnormalities of cardiomyocyte electrical behavior. Notable for their absence of structural heart ...

Background: Intramural site of origin is a major cause of ablation failure of ventricular arrhythmias and the optimal strategy is unclear. This study investigated the efficacy of a stepwise ablation ...

Clinical effectiveness of catheter ablation in atrial fibrillation (AF) is typically characterized by 12-month freedom from atrial tachyarrhythmia recurrence. However, freedom from AF burden may serve ...

Background: The PRAETORIAN trial investigated the efficacy and safety of the subcutaneous implantable cardioverter-defibrillator (S-ICD) compared with transvenous ICD (TV-ICD) and showed ...