In the recent article, “Antisense Oligonucleotide Therapy for Calmodulinopathy,” we provided the first proof-of-concept in ...

The growing morbidity, mortality, and health care costs related to heart failure (HF) underscore the urgent need to prioritize its primary prevention. Whereas a risk-based approach for HF prevention ...

Elevated plasma levels of Lp(a) [lipoprotein(a)] are a causal risk factor for coronary heart disease and stroke in European individuals, but the causal relevance of Lp(a) for different stroke types ...

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The recent study by Bortolin et al, 1 “Antisense Oligonucleotide Therapy for Calmodulinopathy,” presents an innovative therapeutic strategy for rare inherited arrhythmia syndromes. By leveraging ...

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The adult vascular system is a developmental mosaic. This is particularly true for vascular SMCs that comprise the medial layer of blood vessels throughout the body. 1 SMCs are specialized ...

Such findings were generally ignored because multiple epidemiological studies have demonstrated reduced cardiovascular disease (CVD) events with increasing levels of physical activity (PA). Randomized ...

Our vision is to innovate and incorporate promising technologies to communicate freely available, high-priority, high-quality content, which accelerates scientific progress and advances heart and ...

Few middle-aged and older adults engage in regular leisure-time exercise. Incidental physical activity (IPA) encompasses activities of daily living outside the leisure-time domain. No dose-response ...