According to Exicure, AST-005 can penetrate the skin when applied topically and knockout the TNF gene of interest due to the unique ability of SNA constructs.

Alleles of TNF and nearby genes are associated with susceptibility to numerous immunopathological diseases, including type I diabetes and myasthenia gravis. 1 However, the precise gene(s) or ...

For example, just one anti-TNF iteration from corporate giant Johnson and Johnson, called Remicade, accounted for nearly 10 percent of that company’s entire global revenue in 2013. The drugs are ...

Details of vector structure and production have been previously described. 20. ... Tumor necrosis factor-alpha-based gene therapy enhances radiation cytotoxicity in human prostate cancer.

Duke researchers now have discovered that a gene called uhrf1 acts like a kind of molecular handbrake on TNF. In the absence of uhrf1, TNF rolls out a series of pro-inflammatory and immune signals ...

A specific variant of the TNF-alpha gene predicts faster progression of rheumatoid arthritis. (American College of Rheumatology 2004 meeting.) ...

In these two patients, the TNF gene failed to function, preventing the respiratory burst from occurring, and thus the creation of ROS molecules. As a result, the patients' alveolar macrophages ...

Cite this: Novel TNF-alpha Vector and Gene May Enhance Chemoradiation for Esophageal Cancer - Medscape - Jan 25, 2010. Authors and Disclosures. Authors and Disclosures Journalist ...

The two were the only members of their extended family with a mutation in the TNF gene, which encodes for proteins linked to the regulation of a variety of biological processes. Short for "tumor ...

Children and adolescents with Crohn’s disease who received anti-tumor necrosis factor-alpha therapy showed rapid improvement in trabecular bone mineral density and cortical structure besides ...

In this issue of the Journal of Clinical Oncology, Senzer et al describe the results of their phase 1 gene transfer trial of TNFerade. The goal of this trial was to take advantage of the well-known ...