Scientists at St. Jude Children's Research Hospital have reconciled two closely related but contentious mechanisms underlying ...

Cornell researchers have found a new and potentially more accurate way to see what proteins are doing inside living cells - using the cells' own components as built-in sensors.

Proteins are the infinitely varied chemicals that make cells work, and science has a pretty good idea how they are made. But ...

A second polymorphism in the TNF gene promoter (-308 G/A) that results in elevated serum TNF levels has also been found to be over-represented in early onset sporadic PD. [156, 157] Lastly, TNFR1 ...

Abstract Currently, investigations have focused on the identification of Single Nucleotide Polymorphisms (SNP) involved in host response and its ability to generate an immunity deficiency. The aim of ...

Carboxy terminal BRCT domains of the breast cancer susceptibility gene 1 (BRCA1) bind to phosphorylated proteins through a pSXXF consensus recognition motif. We report a systematic structure–activity ...

3.3 Conserved motifs, protein structure, and gene structure analysis of NbPLCPs We analyzed the gene structure of NbPLCPs, and showed that these genes contained more than one exon, ranging from 1 to ...

The AGT gene encodes the only known glycoprotein precursor of the potent vasopressor Ang II and is transcriptionally activated in hepatocytes during the acute-phase response. 12 Although AGT is ...

A new study from researchers at the University of Rochester, published in Biophotonics Discovery, suggests that differences in the structure of collagen-the main protein in connective tissue-may ...

Background Adalimumab blocks the action of tumor necrosis factor-α and reduces disease progression in rheumatoid arthritis and psoriatic arthritis. The effects of adalimumab in controlling progression ...

Objective To identify predictors of response to tumor necrosis factor (TNF) antagonists in ankylosing spondylitis (AS) and psoriatic arthritis (PsA).Methods Systematic review and meta-analysis of ...

Tumor necrosis factor α (TNF-α) is a central driver of inflammation in autoimmune conditions such as Crohn’s disease and rheumatoid arthritis (RA). Targeting epigenetic regulators involved in cytokine ...