In order to design a ribozyme to cleave TNF-α mRNA, we first had to predict the secondary structure of mTNF-α mRNA to identify an accessible target site for the ribozyme. This was carried out ...

According to Exicure, AST-005 can penetrate the skin when applied topically and knockout the TNF gene of interest due to the unique ability of SNA constructs.

Alleles of TNF and nearby genes are associated with susceptibility to numerous immunopathological diseases, including type I diabetes and myasthenia gravis. 1 However, the precise gene(s) or ...

A specific variant of the TNF-alpha gene predicts faster progression of rheumatoid arthritis. (American College of Rheumatology 2004 meeting.) ...

Duke researchers now have discovered that a gene called uhrf1 acts like a kind of molecular handbrake on TNF. In the absence of uhrf1, TNF rolls out a series of pro-inflammatory and immune signals ...

Children and adolescents with Crohn’s disease who received anti-tumor necrosis factor-alpha therapy showed rapid improvement in trabecular bone mineral density and cortical structure besides ...

The two were the only members of their extended family with a mutation in the TNF gene, which encodes for proteins linked to the regulation of a variety of biological processes. Short for "tumor ...

In this issue of the Journal of Clinical Oncology, Senzer et al describe the results of their phase 1 gene transfer trial of TNFerade. The goal of this trial was to take advantage of the well-known ...