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But the researchers were particularly interested in the Rh antigens, responsible for the "positive" and "negative" classifications. These antigens notably influence the risks of hemolytic diseases in ...

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Rh alloimmunization occurs when an Rh-negative mother produces antibodies against Rh-positive blood cells from her fetus, which can lead to hemolytic disease of the fetus and newborn (HDFN).

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In this scenario, called Rh incompatibility, the pregnant person's immune system may create antibodies and attack the fetus's red blood cells, leading to hemolytic disease of the newborn.

In a recent study, non-invasive prenatal testing was able to help researchers diagnose fetal anemia earlier during pregnancy.