Protease-activated receptors (PARs) are a family of G-protein-coupled receptors activated by proteolytic cleavage, notably by coagulation proteases such as thrombin and factor Xa. In chronic kidney ...
Inappropriate activation and aggregation of platelets can lead to arterial thrombosis. Thrombin is the most potent platelet agonist that activates human platelets via two PARs (proteinase-activated ...
Objective— Protease-activated receptor-1 (PAR1) mediates the thrombin-induced proliferation and hypertrophy of vascular smooth muscle cells. A role of Rac1 in the regulation of PAR1 expression was ...
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Sutro Biopharma underwent major restructuring, including management changes and layoffs. Read why I rate STRO stock a Strong ...
Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2 Article Open access ...
∥ Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States ⊥ The Scripps Research Institute Molecular Screening Center, 10550 North Torrey Pines Road, La ...
Discussion: Together, these findings support PAR1 as an endogenous model of protease-dependent functional selectivity that, in our heterologous assay systems, separates signaling along a ...
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