Protease-activated receptors (PARs) are a family of G-protein-coupled receptors activated by proteolytic cleavage, notably by coagulation proteases such as thrombin and factor Xa. In chronic kidney ...
Protease-activated receptors (PARs) are a unique subfamily of G protein-coupled receptors that mediate the interface between coagulation and inflammatory cascades. Four family members (PAR1–PAR4) are ...
Objective— Protease-activated receptor-1 (PAR1) mediates the thrombin-induced proliferation and hypertrophy of vascular smooth muscle cells. A role of Rac1 in the regulation of PAR1 expression was ...
∥ Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States ⊥ The Scripps Research Institute Molecular Screening Center, 10550 North Torrey Pines Road, La ...
Discussion: Together, these findings support PAR1 as an endogenous model of protease-dependent functional selectivity that, in our heterologous assay systems, separates signaling along a ...
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Targeting F2R/PAR1 with ligand decorated lipid nanocarriers for enhanced drug delivery into ovarian cancer cells Riya Khetan Weranga Rajapaksha Bukuru D. Nturubika Todd A. Gillam Doug A. Brooks Sanjay ...
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