The Detroit Lions will host the Buffalo Bills on Sunday during one of the most important games on the Week 15 NFL schedule. Detroit is sitting atop the NFC with a 12-1 record, while Buffalo is looking to bounce back from a 44-42 loss to the Rams.

NFL Week 15 kicked off on Thursday with the visiting underdog Los Angeles Rams knocking of the San Francisco 49ers 12-6. 15 games remain on the schedule, as all 32 teams will play. Every team has had its bye. Sunday’s schedule has seven games kicking off at 1 p.m. ET. Then another five kick off at 4:25 p.m. ET.

Here's everything you need to know for Week 15 NFL games. Which teams will win, who are the X factors and which storylines matter most?