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This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Reported a robust objective response rate of 75.5% from the Phase 1 study of NX-5948 in patients with relapsed/refractory CLL/SLL at the 66th ...

Here, we use a synthetic amphiphile to modulate the membrane mechanical properties of cell-derived vesicles and probe channel activation. Using precise membrane mechanical characterization approaches ...

The Company’s most advanced clinical-stage development program, dordaviprone (ONC201), is in development for H3 K27M-mutant glioma. The Company is conducting Phase 1 dose escalation studies of ONC206 ...

A rumor that Katy Perry donated all revenue from her latest album, 143, to support the victims of the raging California wildfires went viral on X on January 11, 2025. The wildfires in LA ...

Their captain, Brady Tkachuk, has been an absolute mutant on the power play this year, tallying nine times, which has him tied for the third most in the league. Tkachuk and Drake Batherson have ...

The Arizona Department of Transportation says parts of I-10 and SR 143 will be closed near Sky Harbor Airport for continuing work on the Broadway Curve Improvement project. In addition ...

Initial studies of staphylococcal adhesion focused on binding to the extracellular matrix and plasma proteins. More recently, studies have investigated adhesins for human keratinocytes and their ...

To directly examine the interplay between mutant p53 or Mdm2 and wild type p53 in gene occupancy and expression, an integrated RNA-seq and ChIP-seq analysis was performed in vivo using isogenically ...