Multivariable logistic regression was used to identify populations eligible for metformin (i.e., eGFR ≥45 mL/min/1.73 m 2 among individuals with creatinine levels above conventional sCr cutoffs.

Objective Many societies recommend using estimated glomerular filtration rate (eGFR) rather than serum creatinine (sCr) to determine metformin eligibility. We examined the potential impact of ...

KRAS mutations are among the most common genetic alterations in cancer and are considered particularly difficult to treat.

The research on metformin and human longevity is scant, but that hasn’t stopped some people from experimenting with it. By Mohana Ravindranath A few years ago, Marc Provissiero, a movie producer ...

Metformin was associated with significantly reduced knee pain among patients with overweight/obesity and knee osteoarthritis.

Scientists discovered that the diabetes medication metformin can significantly boost egg production in aging chickens.

There is increasing interest in finding drugs, known as gerotherapeutics, that can slow aging and help people live longer.

In acute kidney injury, certain biomarkers—such as urine albumin-to-creatinine ratio and epidermal growth factor—are linked ...

For patients with overweight or obesity and symptomatic knee osteoarthritis, the researchers found that the mean change in VAS pain was −31.3 and −18.9 mm in the metformin and placebo groups ...

Penn State researchers found that metformin helps aging hens lay more eggs by improving hormone balance and liver function.