The San Francisco 49ers suffered a pair of huge blows to their offensive backfield in their Week 13 loss to the Buffalo Bills ...

The 49ers lost running back Christian McCaffrey for the season with a knee injury. His backup, Jordan Mason, will also be ...

San Francisco 49ers running back Jordan Mason is going on injured reserve, head coach Kyle Shanahan announced.

With San Francisco 49ers running back Christian McCaffrey dealing with Achilles tendinitis to begin the year, Jordan Mason ...

The San Francisco 49ers placed running back Christian McCaffrey on injured reserve Tuesday a day after coach Kyle Shanahan ...

The San Francisco 49ers’ dreadful season got worse in Week 13 when running backs Christian McCaffrey and Jordan Mason both ...

The injury to Jordan Mason is a tough blow for a 49ers team that was already preparing itself to miss more time without ...

Suddenly, the Niners' starting running back on Sunday against the Chicago Bears will be rookie Isaac Guerendo with practice ...

The San Francisco 49ers entered this season with lofty aspirations. For the most part, their hopes have been dashed -- and ...

San Francisco 49ers running back Jordan Mason. / Mark Konezny-Imagn Images The San Francisco 49ers lost their top two running backs in Week 13, as Christian McCaffrey was placed on injured reserve ...

The 49ers are expected to place Mason on injured reserve this week after he suffered a high-ankle sprain late in Sunday's 35-10 loss to the Bills, Nick Wagoner of ESPN.com reports. After Christian ...

The 49ers are down to one healthy RB, rookie Isaac Guerendo. They will likely elevate Patrick Taylor Jr. from the practice ...