San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The ...

The San Francisco 49ers have had terrible injury luck this season, which ultimately led to the end of their playoff hopes. Just a few months ago, they were in the overtime of a Super Bowl, but life ...

The 49ers will have running back Isaac Guerendo for Monday Night Football. Guerendo, who missed last week's game with a ...

San Francisco 49ers running back Isaac Guerendo is expected to return from foot and hamstring injuries and play Monday, a ...

The Las Vegas Raiders said goodbye to Josh Jacobs last offseason, which opened a rather big hole in their backfield. It seemed they were going to rely upon youn ...

Arizona State RB Cam Skattebo adds fuel to discussions linking him to San Francisco 49ers draft strategy amid backfield challenges.

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until McCaffrey’s return in Week 10. McCaffrey and Mason were both hurt in a Week ...

The San Francisco 49ers list of players on injured lists ballooned to 16 ... wide receiver Brandon Aiyuk and running back ...