The San Francisco 49ers have had terrible injury luck this season, which ultimately led to the end of their playoff hopes. Just a few months ago, they were in the overtime of a Super Bowl, but life ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

The San Francisco 49ers list of players on injured lists ballooned to 16 ... wide receiver Brandon Aiyuk and running back ...

"After losing RBs Christian McCaffrey, Jordan Mason, and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday's game vs. Miami.

The San Francisco 49ers have been bitten badly by the injury ... which entered play on Sunday with running backs Christian McCaffrey, Jordan Mason and Elijah Mitchell on IR. Things only worsened ...

The 49ers have been without Isaac Guerendo for most of December. But the RB helped provide a promising update Thursday.

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

After placing RBs Jordan Mason and Christian McCaffrey on the IR, the 49ers are now promoting RB Patrick Taylor Jr. to the active roster. Considering that there’s only 5 games left in the season ...

On Sunday, the San Francisco 49ers traveled to State Farm Stadium to take on the Arizona Cardinals, looking for only their seventh win of the season.

The 49ers' 2024 campaign is over ... The others are Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring). Guerendo, a 2024 fourth-round pick, proved to be effective ...

Guerendo has risen to the top of a 49ers depth chart at the position that has been decimated by injury this season. Christian McCaffrey, Jordan Mason and Elijah Mitchell all sustained season ...