SANTA CLARA, Calif. — Some kids are just born to run. Isaac Guerendo’s mother, Jen, realized that early on. She remembers a family gathering at a park in southern Indiana during which the kids ...

Ranked 44th at his position and 193rd overall in the NFL, Guerendo had 79.2 fantasy points (5.0 per game) last season.

The San Francisco 49ers got a great performance out of rookie running back Isaac Guerendo in his first career NFL start in Week 14 against the Chicago Bears. However, the fourth-round rookie ...

Since joining the 49ers, Isaac Guerendo's rise to significant snaps came in the wake of injuries to star running backs Christian McCaffrey, Elijah Mitchell, and the up-and-coming Jordan Mason.

That was until Isaac Guerendo showed up. The rookie fourth-round pick in 2024 stepped into action on Sunday in Week 14, dominating the Bears to the tune of 128 total yards and two touchdowns.

SANTA CLARA — When Isaac Guerendo trots onto the field with the first team Sunday at Levi’s Stadium, he will equal the same number of starts he had in five years of college football.

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac Guerendo with some Patrick Taylor Jr. thrown in for good measure and it was ...

Former Louisville football player and San Francisco 49ers rookie running back Isaac Guerendo busted out a 76-yard carry yesterday during Thursday Night Football to clinch the victory for the 49ers ...

That’s rookie running back Isaac Guerendo, who’s wearing that No. 49. His preseason debut in Friday’s 24-24 tie against the Las Vegas Raiders was an electric one, thanks especially to a 93 ...