Ranked 44th at his position and 193rd overall in the NFL, Guerendo had 79.2 fantasy points (5.0 per game) last season.

The 49ers also picked Jordan James in the fifth round out of Oregon, and Cohn is a fan. "At this point in McCaffrey's care ...

SANTA CLARA, Calif. — Some kids are just born to run. Isaac Guerendo’s mother, Jen, realized that early on. She remembers a family gathering at a park in southern Indiana during which the kids ...

A now-healthy Christian McCaffrey is expected to carry most of the San Francisco 49ers' rushing workload in 2025. Behind him ...

The San Francisco 49ers got a great performance out of rookie running back Isaac Guerendo in his first career NFL start in Week 14 against the Chicago Bears. However, the fourth-round rookie ...

SANTA CLARA — When Isaac Guerendo trots onto the field with the first team Sunday at Levi’s Stadium, he will equal the same number of starts he had in five years of college football.

That was until Isaac Guerendo showed up. The rookie fourth-round pick in 2024 stepped into action on Sunday in Week 14, dominating the Bears to the tune of 128 total yards and two touchdowns.

Since joining the 49ers, Isaac Guerendo's rise to significant snaps came in the wake of injuries to star running backs Christian McCaffrey, Elijah Mitchell, and the up-and-coming Jordan Mason.

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac Guerendo with some Patrick Taylor Jr. thrown in for good measure and it was ...

Former Louisville football player and San Francisco 49ers rookie running back Isaac Guerendo busted out a 76-yard carry yesterday during Thursday Night Football to clinch the victory for the 49ers ...

It's the fantasy football playoffs, so you know it's no time to mess around. And what we've got with Isaac Guerendo is some risk. The San Francisco 49ers running back is questionable with a ...