Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

ESPN’s Adam Schefter reported that San Francisco 49ers running back Isaac Guerendo will try to play tonight against the Los ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

DE Nick Bosa (hip, oblique), RB Isaac Guerendo (foot) and LB Dre Greenlaw (Achilles ... Unsurprisingly, a running back with size (6-0, 221 pounds) and speed (4.33 40-yard dash) performed well in Kyle ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Brock Purdy passed for 325 yards and two touchdowns, Isaac Guerendo ran for two scores and Leonard Floyd registered two sacks ...

Here’s one way to view the San Francisco 49ers’ running back situation: They were down to their fourth option Sunday, after injuries sidelined Christian McCaffrey, Jordan Mason and Elijah Mitchell.

In his insightful rundown for the first round of the fantasy playoffs, Jake Ciely notes that Rico Dowdle has been on a RB1 ...

It's been a rough stretch for the 49ers in recent weeks and they are taking out their frustrations on the Bears.

Running back Isaac Guerendo caps off San Francisco 49ers' efficient drive with a touchdown run. Watch all of the highlights from the matchup between the Los Angeles Chargers and Kansas City Chiefs in ...

San Francisco 49ers running back Isaac Guerendo turns on the burners with a 30-yard dash. Watch the best rushes from Week 14 of the 2024 NFL season.

The 49ers quickly built on that strong start with a couple more touchdowns, including a second hookup between Purdy and ...