Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

A situation developed just before the Fantasy playoffs that delivered us a potential league-winning running back. Christian ...

Starter Christian McCaffrey (knee) is amid his second IR stint, and his backup, Jordan Mason, is also on IR with a high-ankle ...

Here’s one way to view the San Francisco 49ers’ running back situation: They were down to their fourth option Sunday, after injuries sidelined Christian McCaffrey, Jordan Mason and Elijah Mitchell.

The San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by a former Offensive Player of ...

The 49ers' run game suffered a significant setback at the beginning of the season when it was determined that Christian ...

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Henry will be the only must-start member of this backfield when they return in Week 15 to face the Giants. James Cook (Week ...

As the first quarter wound down in his second NFL game, San Francisco 49ers running back Isaac Guerendo trotted on to ... 221-pound speedster (he ran the 40-yard dash in 4.33 seconds at the ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

Isaac Guerendo is expected to step in as the San Francisco 49ers' starting running back after injuries to Christian McCaffrey ...