Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...

The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have started ...

The 49ers will have running back Isaac Guerendo for Monday Night Football. Guerendo, who missed last week's game with a ...

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

Juszczyk (illness) didn't practice Friday, Nick Wagoner of ESPN.com reports.

Can the Lions clinch the NFC 1-seed with a win? We continue our NFL odds series with a Lions-49ers prediction and pick.

After missing last week because of a hamstring injury, San Francisco 49ers running back Isaac ... which has put Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle ...

The last-place 49ers (6-11) lost seven of their final eight and did so with a generous defense that failed to produce a ...