McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

The San Francisco 49ers on Tuesday announced how they’d replace running back Christian McCaffrey ... they need depth at WR or on special teams. We may see additional roster moves in the ...

ORCHARD PARK, N.Y. -- San Francisco 49ers running back Christian McCaffrey suffered what ... And for about 18 minutes, ...

Head coach Kyle Shanahan may give some insight into the injury after the game, but it may be Monday before we get any other updates on the injury severity. 49ers RB Christian McCaffrey has been ...

San Francisco 49ers running back Christian McCaffrey has spoken out after being placed on injured reserve with yet another ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.

After sustaining yet another injury, it sounds like San Francisco 49ers running back Christian McCaffrey will now miss ...

San Francisco 49ers star Christian ... notable names in McCaffrey's post. "I love you so much. So proud of you always," commented McCaffrey's wife, Olivia Culpo. "we’re all here man, ain ...

In 40 other games at Wisconsin and Louisville, Guerendo played in a shared backfield –something he’s done with the 49ers this season behind Jordan Mason and Christian McCaffrey. With McCaffrey ...

ORCHARD PARK, N.Y. -- San Francisco 49ers running back Christian McCaffrey ... And for about 18 minutes, McCaffrey's teammates believed it was happening. "We all saw what he was doing, and he ...