Recently, Spain designated allopurinol as the first orphan medicine for Marfan syndrome under the European Medicines Agency (EMA) criteria. Under European Union rules, orphan medicine is a drug ...

Robert Keenan presented long-term safety and tolerability of pozdeutinurad alone or in combination with allopurinol in gout patients with subcutaneous tophi—data from a Phase II open-label trial.

Amoxicillin has interactions with some other drugs. Examples include warfarin, methotrexate, and allopurinol. Talk with your doctor to avoid potentially harmful effects from amoxicillin interactions.

First-line medications for lowering uric acid include the oral xanthine oxidase inhibitors allopurinol and febuxo-stat; IV pegloticase (Krystexxa, Amgen) can be used in advanced CKD with severe ...

Current first-line therapies like allopurinol and febuxostat can be very effective, but some patients – roughly 1% according to FDA estimates – don’t get the hoped-for benefit, while others ...

Miltefosine (MIL)–allopurinol combination therapy administered at standard dosage is effective to treat canine leishmaniosis, nevertheless for some dogs the digestive tolerance of MIL is not ...

Objective To assess the effect of allopurinol use on the risk of incident atrial fibrillation (AF) in the elderly. Methods We used the 5% random Medicare Claims data from 2006 to 2012 to examine the ...

Objectives To quantify the risk of non-fatal acute myocardial infarction (AMI) among users of allopurinol. Methods We carried out a population-based case–control study over the period 2001–2007 in ...

Objectives: To compare the efficacy and tolerability of allopurinol 300–600 mg/day versus benzbromarone 100–200 mg/day used to attain a target serum urate concentration (sUr) ⩽0.30 mmol/l (5 mg/dl).

Introduction Reported adherence to urate-lowering therapy (ULT) in gout varies widely (17%–83.5%). Variability may partly be due to different adherence measurement ...

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