The 49ers are in a good spot to land pass rush help … or Ashton Jeanty … in the 1st round of this year’s draft.

Christian McCaffrey suffered what turned out to be a season-ending knee injury in the San Francisco 49ers’ Week 13 loss to ...

San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has ...

Rookie running back Isaac Guerendo was carted off the field less than two minutes into the first quarter during the 49ers’ ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

Rookie running back Isaac Guerendo was carted off the field less than two minutes into the first quarter during the 49ers’ ...

San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the ...

San Francisco 49ers rookie RB Isaac Guerendo suffered MCL and ankle sprains against the Arizona Cardinals, avoiding an ACL ...

The 49ers lost their standout rookie Isaac Guerendo in scary fashion. What update did the running back provide Monday?

In the Arizona Cardinals’ 47-24 victory over the San Francisco 49ers, 23 players participated in at least one of the 76 ...

San Francisco running back Isaac Guerendo exited the 49ers' season finale versus the Arizona Cardinals just four plays into ...

The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have started ...