The Arizona Cardinals face the San Francisco 49ers in their season finale and have made roster moves to prepare for the game ...

San Francisco 49ers running back Isaac Guerendo is dealing with a ... Guerendo has risen to the top of a 49ers depth chart at the position that has been decimated by injury this season.

The ongoing epidemic in the San Fransisco 49ers' backfield just spread a bit further. 49ers running back Isaac Guerendo San Fransisco is officially listed as out for Sunday's game against the ...

The San Francisco 49ers will roll out a fourth different starting running back Sunday when they visit ... those season totals Sunday with unreliable depth behind him. Ke'Shawn Vaughn will likely ...