Childhood obesity remains a pressing global health challenge, yet the impact of dynamic adiposity changes during active developmental window retains poorly understood. Leveraging longitudinal data ...

Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.

Cryo-EM structures of 70S•RelA ribosome complexes reveal how cognate deacyl-tRNA activates RelA.

Brain organoids, also known as brain spheroids, are three-dimensional cultures of neural cells derived from pluripotent stem cells (PSCs) that mimic the brain’s organization, development, and activity ...

Neuroscientist Roya Huang tells us about their experience of publishing in the eLife Model. Roya Huang is a Postdoctoral Fellow in the Department of Molecular and Cell Biology, University of ...

eLife reviews research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we review and sign up ...

Noticeable noises in the background, such as a phone ringing, shift our attention by activating the same circuit of nerves that we use when focusing on specific sounds. When walking into a busy ...

New funding, awards for metadata and UX excellence, and outstanding research articles are among the highlights of the past year at eLife. Last week, Wellcome announced a £2.4m investment in eLife ...

eLife has changed its editorial process to eliminate accept/reject decisions after peer review and instead provide readers with richer and more nuanced assessments of articles. eLife changed its ...

Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis ...

where ΔG (γ = 0) is the free energy difference at zero tension, γ the membrane tension and ΔA the in-plane cross sectional area change associated with channel opening (Haswell et al., 2011). Thus, ...

This important study combines convincing live cell imaging and mathematical modeling data to show how an emerging model fungus engages in an oscillatory chemical dialogue to prepare for cell-cell ...