Objective Colorectal cancer is primarily treated with surgery. Major surgery and older age are risk factors associated with postoperative decline in cognitive function. In clinical research, a wide ...

Original research: Cost-effectiveness of percutaneous mitral repair for patients with severe secondary mitral regurgitation: an updated evaluation using a modelling approach based on COAPT final data ...

Objective To synthesise qualitative studies that explore prescribers’ perceived barriers and enablers to minimising potentially inappropriate medications (PIMs) chronically prescribed in adults.

Introduction Early warning scores (EWSs) are used extensively to identify patients at risk of deterioration in hospital. Previous systematic reviews suggest that studies which develop EWSs suffer ...

1 Centre of Expertise on Quality and Safety, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands Objective Although the guiding principle of clinical governance ...

Setting England between 2001 and 2010. Participants All people whose death was registered in England between 2001 and 2010 and whose certificate contained a sepsis-associated International ...

Objectives The purpose of this study is to map the characteristics of the existing medical literature describing the medications, settings, participants and outcomes of medical assistance in dying ...

Objectives Multimorbidity—the co-occurrence of at least two chronic diseases in an individual—is an important public health challenge in ageing societies. The vast majority of multimorbidity research ...

Objectives To evaluate the efficacy and safety of intra-articular (IA) bupivacaine administered for pain relief after joint arthroplasty. Design Meta-analysis. Methods A systematic review was ...

Introduction Inspiratory muscle training (IMT) has been applied during pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). However, it remains unclear if the ...

Introduction Children diagnosed with developmental coordination disorder (DCD) exhibit a range of challenges in both gross ...

Background The main aim of sanitation is to prevent human contact with faecal pathogens to decrease occurrences of diseases. However, no region in the world is on the right track to accomplish ...